Santilli is an Italian surname. Notable people with the surname include:
Antonia Santilli (born 1949), Italian actress and model
Ivana Santilli (born 1975), Canadian R&B singer and multi-instrumentalist
Diego Santilli (born 1967), Argentine politician
Mario Santilli (born 1984), Argentine footballer
Ray Santilli (born 1958), British musician, record, and film producer
Roberto Santilli (born 1965), Italian volleyball coach
Ruggero Santilli (born 1935), Italian-American nuclear physicist known for his fringe science
