Trafficante may refer to:
Trafficante crime family, mafia crime family in the state of Florida.
Santo Trafficante Sr. (1886–1954) Sicilian-born mobster, and father of the powerful mobster Santo Trafficante Jr.
Santo Trafficante Jr. (1914–1987) Powerful Tampa, Florida-born mobster, son of mobster Santo Trafficante Sr.
