Sandrini is an Italian surname. Notable people with the surname include:
Domenico Sandrini (1883–1973), Italian cross-country skier, Nordic combined skier, and ski jumper
Luis Sandrini (1905–1980), prolific Argentine comic film actor and film producer
Mattia Sandrini (born 1993), Italian footballer
Peter Sandrini (born 1961), Italian-born translation theorist and terminologist
