Charles Penrose may refer to:
Charles Penrose (entertainer) (1873–1952), English music hall and theatre performer, and radio comedian
Charles Penrose (rower) (1816–1868), English rower, schoolteacher and clergyman
Charles Penrose (Royal Navy officer) (1759–1830)
Charles B. Penrose (1798–1857), Pennsylvania attorney and politician
Charles Bingham Penrose (1862–1925), Philadelphia gynecologist and grandson of Charles B. Penrose
Charles W. Penrose (1832–1925), member of the Quorum of the Twelve Apostles of The Church of Jesus Christ of Latter-day Saints
