Opposite sex may refer to:
A phrase used in the discussion of sex or gender
Dioecy, a characteristic of a species, meaning that it has distinct male and female individual organisms
Heterosexuality, the romantic attraction, sexual attraction or sexual behavior between persons of the opposite sex or gender
The Opposite Sex, a 1956 musical film, directed by David Miller
The Opposite Sex (2014 film), directed by Jennifer Finnigan and Jonathan Silverman
Opposite Sex (TV series), a 2000 TV series
The Opposite Sex: Rene's Story and The Opposite Sex: Jamie's Story, a 2004 two-part story which is part of the Real Momentum documentary series
