William Burden may refer to:
William Burden (tenor), American tenor
William Fletcher Burden (1830–1867), American industrialist
William A. M. Burden Sr. (1877–1909), American football player and stock broker
William Douglas Burden (1898–1978), American naturalist and author
William A. M. Burden (1906–1984), American Ambassador to Belgium
Doug Burden (William Douglas Burden, born 1965), American rower
